Biological Chemistry of Arsenic, Antimony and BismuthHongzhe Sun Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison - and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia - it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections. Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include:
Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry. |
Contents
Arsenics Interactions with Macromolecules and its Relationship | 19 |
Biological Chemistry of Antimony and Bismuth | 53 |
Metallomics Research Related to Arsenic | 83 |
Arsenic in Traditional Chinese Medicine | 113 |
References | 130 |
Acknowledgements | 142 |
Biomethylation of Arsenic Antimony and Bismuth | 145 |
Abbreviations | 174 |
References | 239 |
References | 259 |
Application of Arsenic Trioxide Therapy for Patients | 263 |
Acknowledgements | 286 |
Anticancer Activity of Molecular Compounds of Arsenic Antimony | 293 |
Radiobismuth for Therapy | 311 |
Genetic Toxicology of Arsenic and Antimony | 331 |
345 | |
Metalloid Transport Systems | 181 |
References | 203 |
Bismuth Complexes of Porphyrins and their Potential | 209 |
Metalloproteomics of Arsenic Antimony | 353 |
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acid activity anticancer antimony antimony and bismuth APL patients apoptosis Applied Organometallic Chemistry Applied Pharmacology AQP9 ArsA arsenic metabolites arsenic species arsenic trioxide arsenite arsenolite As(V AsIII atoms bacteria BiIII binding Biological Chemistry bismuth compounds blood boron carcinogenesis cell lines cellular Chemical Society clinical complex concentrations coordination cysteine cytotoxicity demonstrated detected DMA(V DMAIII DMAV DNA methylation DNA repair dose drugs effects efflux elements Environmental enzyme excreted exposure gene glutathione hamsters human ICP-MS induced inhibition inorganic arsenic Journal of Biological Leishmania leukaemia ligand liver Me3Bi mechanism Medicine membrane metabolism metal metalloid metallomics methylantimony mice microbial Microbiology molecular molecules oxidative stress pathway peptides pnictogen porphyrin potential protein pylori RBCs realgar reduced reductase reported Research in Toxicology residues SbIII Sciences speciation structure studies targets therapeutic therapy toxicity Toxicology Toxicology and Applied transferrin transport treatment trivalent arsenicals tumor uptake urine vitro vivo