Biological Chemistry of Arsenic, Antimony and Bismuth

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Hongzhe Sun
John Wiley & Sons, Dec 10, 2010 - Science - 400 pages
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Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison - and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia - it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections.

Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include:

  • chemistry of As, Sb and Bi
  • biological chemistry of arsenic
  • biological chemistry of Sb and Bi
  • arsenic and antimony speciation in environmental and biological samples
  • arsenic in traditional chinese medicine
  • arsenic in aquifers
  • biomethylation of As, Sb and Bi
  • uptake of metalloids by cells
  • bismuth complexes of porphyrins and their potential in medical applications
  • Helicobacter pylori and bismuth
  • metabolism of arsenic trioxide in blood of the acute promyelocytic leukemia patients
  • anticancer properties of As, Sb and Bi
  • radio-Bi in cancer therapy
  • genotoxicity of As, Sb and Bi
  • metallomics as a new technique for As, Sb and Bi
  • metalloproteomics for As, Sb and Bi

Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry.

 

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Contents

Arsenics Interactions with Macromolecules and its Relationship
19
Biological Chemistry of Antimony and Bismuth
53
Metallomics Research Related to Arsenic
83
Arsenic in Traditional Chinese Medicine
113
References
130
Acknowledgements
142
Biomethylation of Arsenic Antimony and Bismuth
145
Abbreviations
174
References
239
References
259
Application of Arsenic Trioxide Therapy for Patients
263
Acknowledgements
286
Anticancer Activity of Molecular Compounds of Arsenic Antimony
293
Radiobismuth for Therapy
311
Genetic Toxicology of Arsenic and Antimony
331
References
345

Metalloid Transport Systems
181
References
203
Bismuth Complexes of Porphyrins and their Potential
209
Metalloproteomics of Arsenic Antimony
353
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About the author (2010)

Dr Hongzhe Sun, Department of Chemistry, The University of Hong Kong
Dr. Sun's research interests lie in the chemistry of metals in biology and medicine. He has been invited to deliver lectures in various international conferences including the prestigious "Gordon Conference on Metals in Medicine" and "International Conference on Biological Inorganic Chemistry". He has published over 80 papers in solid chemical and biochemical journals. He serves in the Editorial Advisory Board of The Journal of Biological Inorganic Chemistry (Springer, 2007-2009) and The Open Medicinal Chemistry Journal (Bentham Science Publisher).

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