Biological Chemistry of Arsenic, Antimony and BismuthHongzhe Sun Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison - and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia - it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections. Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include:
Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry. |
Contents
Arsenics Interactions with Macromolecules and its Relationship | |
Carcinogenesis in Animals and Man Metabolism and Analytical Chemistry | 2 |
Biological Chemistry of Antimony and Bismuth | 8 |
Metallomics Research Related to Arsenic | 36 |
Acknowledgements | 64 |
Microbial Transformations of Arsenic in Aquifers | 88 |
References | 94 |
Metalloid Transport Systems | 133 |
Bismuth Complexes of Porphyrins and their Potential in Medical | 158 |
Helicobacter pylori and Bismuth | 188 |
Application of Arsenic Trioxide Therapy for Patients with | 198 |
Acknowledgements | 206 |
Anticancer Activity of Molecular Compounds of Arsenic | 169 |
Radiobismuth for Therapy | 177 |
References | 185 |
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acid activity anticancer antimony antimony and bismuth antimony(III apoptosis Applied Pharmacology AQP9 ArsA arsenic metabolites arsenic species arsenic trioxide arsenite arsenolite As(III As(V atoms bacteria binding Biochemical Biochemistry Biological Chemistry bismuth compounds blood boron cancer cell carcinogenesis cell lines cellular Chemical Research Chemical Society cisplatin clinical complex concentrations coordination cysteine cytotoxicity detected DMA(III DMA(V DNA methylation dose drugs effects efflux Environmental enzyme exposure gene hamsters human ICP-MS induced inhibition inorganic arsenic interaction Journal of Biological Leishmania leukaemia ligand mechanism Medicine membrane metabolism metal metalloid Metallomics methylantimony methylation mice Microbiology Molecular molecules oxidative stress pathway peptides Pharmacology pnictogen porphyrin potential protein Proteomics pylori RBCs realgar reduced reductase reported Research in Toxicology Reviews Rosen Sciences speciation structure studies targets therapeutic therapy toxicity Toxicology Toxicology and Applied transferrin transport treatment trivalent arsenicals tumor uptake urine vitro vivo Wang